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KMID : 0357919740080010043
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Korean Journal of Pathology
1974 Volume.8 No. 1 p.43 ~ p.47
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Intrahepatic Colloid Deposit in Kupffer Cell
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김용일(金勇一)/Yong Il Kim
이진수(李振洙)/구재훈(丘在勳)/Jin Soo Lee/Jae Hoon Koo
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Abstract
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A histologic and histochemical study on ten cases of the liver needle biopsy
specimens disclosing smudgy, pale basophilic, globular, aggregations mainly localized
within the hepatic Kupffer cells, was made to clarify the nature of substance and tissue
reaction.
1. The material lay mainly with in Kupffer cells freely in the hepatic sinusoids or in
the portal spaces.
2. Hematoxylin-eosin stained sections revealed aggregations of pale to deep blue
globular substance measuring 10-100 μ in diameter, and accompanied a mild
lymphocytic and histiocytic reaction except in one which was characterized by foreign
body type granulomas.
3. Histochemical reaction of the material to PAS, mucicarmine and alcian blue stains
gave all negative reactions.
4. Two cases presented histories of receiving either periston and/or dextran as plasma
expander.
5, These all of cases revealed no hepatic dysfunction in regard to the deposit.
6. Nature and pathogenesis of the colloidal material were not identified but it is
suggested that deposit of certain exogenous nonmucinous substances as with polyvinyl
pyrrolidone would participate on to the intrahepatic colloidal deposit.
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